A significant number of American adults struggle with substance abuse issues, with one source estimating that 15 percent of adults in the U.S. deal with alcohol, drugs, or other substances. Drug and alcohol misuse can alter brain function, making it harder to quit even with high motivation. NAD therapy, a revolutionary IV treatment that harnesses naturally occurring coenzymes, can help you detoxify and heal.

NAD Therapy

What is NAD?

NAD (nicotinamide adenine dinucleotide) is a coenzyme of niacin present in all living cells and essential to healthy metabolic function. It helps your body transform nutrients into energy, affects cellular function, and promotes various chemical reactions within each cell. As we age, NAD levels decrease, affecting brain function, mitochondrial function, and overall cellular energy production. Factors like high blood glucose, DNA damage, autoimmune disorders, and substance abuse also lower NAD levels.

A healthy lifestyle that includes regular exercise and a balanced diet that is low in processed carbohydrates can help boost NAD levels somewhat, but it might not be enough to counteract severely depleted NAD levels. This is especially true during the detoxification process, which can be particularly stressful both physically and emotionally.

What is NAD Therapy?

NAD therapy involves administering NAD via intravenous infusion to support overall health. This therapy aims to restore healthy NAD levels, which decline due to aging or other medical conditions. NAD IV therapy can help with post-COVID syndrome, chronic fatigue syndrome, high blood pressure, heart failure, and detoxifying from substance abuse disorders.

NAD therapy is also commonly used in people detoxifying from substance abuse disorders.

Research indicates that NAD therapy can help alleviate the biochemical processes associated with addiction. Using NAD therapy during the detoxification process can help reduce cravings, soothe withdrawal symptoms, and support sobriety while promoting overall health.

Is NAD Therapy Effective?

Research shows that NAD levels influence several aspects of the brain and behavior, including anxiety and depression. They also are linked to the part of the brain linked to addiction: the reward center. Substance abuse and substance use disorders have previously been linked to oxidative stress, altered sleeping habits, inflammation, and impaired metabolism. Therefore, the interrelated functions between NAD and its processes can affect addiction and its neurobiology in a variety of ways.

While the jury is still out on how NAD can support people most effectively, there is evidence that it is beneficial for people with substance use disorders. In studies involving NAD therapy and those with alcohol abuse or opioid addiction, NAD IV infusions were administered regularly to support detoxification and reduce withdrawal symptoms. Later studies combined NAD therapy with amino acids and vitamins to create more targeted therapies designed to address cravings, anxiety, and stress.

Currently, NAD is classified as a supplement rather than a medication, which means that it is available without a prescription.

What to Expect during Therapy

During NAD Therapy, you will have an IV placed through which the co-enzyme is dripped into your bloodstream gradually. This allows the treatment to bypass the stomach and travel directly into the bloodstream where it is needed to boost awareness, mood, and energy naturally and without drugs.

Because NAD is not considered a drug or medication but rather a supplement, it can be administered without a doctor’s prescription. However, this also means that insurance might not cover the process.

For most people, NAD therapy is considered safe, but some people may experience mild side effects during or after infusions. These can include:

  • Redness, tenderness, or swelling at the injection site
  • Bruising at the injection site
  • Cramping
  • Nausea
  • Brain fog

Infection and phlebitis at the injection site can also occur but are rare.

If you experience side effects during your infusion, the IV drip can be adjusted to a slower rate, decreasing or eliminating your side effects.

When a medical professional dosed, administered, and monitored NAD therapy, the overall risks are generally low.

The Benefits of NAD Therapy

NAD therapy can offer several significant benefits beyond combating cravings and easing withdrawal symptoms for those recovering from substance abuse and addiction.

Drugs and alcohol can significantly deplete your natural supply of NAD. NAD infusions replenish this supply, which then supports your body’s energy levels without leaving you craving caffeine or other substances. NAD can also help detoxify, flushing out any remaining substances or drugs in your body, which can further reduce symptoms and help you get on the road to sobriety even faster.

Withdrawal symptoms can be a major hurdle to sobriety for many people struggling with substance abuse and addiction. These symptoms can include headache, irritability, anxiety, nausea, vomiting, and seizures. During the process, medical supervision and proper treatment, including NAD therapy, can significantly reduce the risk of withdrawal symptoms. This can then translate to a decreased risk of relapse and an increased ability to focus on therapy and healing for long-term success.

Finally, NAD therapy can help you experience a more natural detoxification experience. Many people who are withdrawing from opioids or other drugs have the option to use certain medications during their treatment. These medications can ease their symptoms but are not without risk. NAD therapy uses a naturally occurring coenzyme that eases withdrawal symptoms without the risk of new addiction or dependence and reduces the need for additional narcotic medications as you detoxify. It can help reduce cravings, which could increase your odds of success.

Is NAD Therapy Right for You?

Drugs, alcohol, and other substances can deplete your body’s natural stores of NAD while infusions can replenish and restore them to healthy levels. NAD therapy can make the withdrawal process easier by curbing cravings, stimulating your energy, and boosting your mood.

It goes a step further than that, however. The naturally occurring coenzyme is essential for cellular health, converting the food you eat into fuel for your body. Without NAD, your body and brain become quickly deprived of energy and unable to repair DNA and cells. An IV treatment can restore your natural NAD levels and help you feel better almost immediately.

This is especially important for those who are overcoming substance abuse and addiction disorders, which can deplete your NAD levels. Daily or weekly infusions can help you get back to where you need to be.


NAD therapy is most effective when used as part of a comprehensive treatment program that includes therapy and other targeted treatments. It is a powerful support for substance use disorder recovery, helping individuals detoxify, heal, and embrace a healthier life. At Long Island Interventions, we offer personalized NAD therapy to help you on your journey to health and sobriety. Contact us today to learn more.


Published on: 2022-07-29
Updated on: 2024-06-21